IDA IN NDD-CKD WHAT YOU SHOULD KNOW

What Is Iron Deficiency?

Iron deficiency (ID) means a shortage of iron, and without enough of it, the body’s red blood cells cannot deliver enough
oxygen to our tissue and organs.1

What Causes Iron Deficiency?

  • Lack of iron in your diet
  • Issues with iron absorption in your gut
  • Increased blood loss
  • Increased need for iron 2

Conditions Linked to Iron Deficiency

  • Chronic kidney disease
  • Chronic heart failure
  • Chronic pulmonary disease
  • Inflammatory bowel disease
  • Chronic autoimmune diseases
  • Cancer
  • Obesity
  • Surgical procedures. 2

Diet

↓ Intake, eg, vegan Malnutrition ↓ Polyphenol/tannins Vitamin C.

↓ Absorption

Gastritis, Drugs Surgery, H. pylori Celiac disease, Enteritis, Bleeding,
Hookworm

Needs

Pregnancy Children EPO/chemotherapy Athletes

Blood Loss

GI lesions/cancer Menorrhagia Blood donations Hematuria
Coagulopathy

Inflammation

IBD Chronic disease (↑Hepcidin)

Other

Hemolysis Iron metabolism disorders

Why Are Patients With CKD More Likely to Have Iron Deficiency?

  • IDA is a common complication of CKD1
  • If you have CKD, you may have lower levels of iron.3
  • Many patients with CKD also have blood loss causing iron deficiency, especially if they are treated with dialysis for kidney failure. 3
  • Patients with CKD often have iron absorption issues due to infections, inflammation, and malnutrition. 3

Symptoms of Iron Deficiency

  • Extreme fatigue
  • Shortness of breath
  • Pale skin
  • Brittle fingernails
  • Body aches and feeling weak
  • Headaches and dizziness
  • Fainting
  • Heart palpitations
  • Chest pain
  • Sleep disturbances
  • Trouble concentrating1,4

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REFERENCES:

  1. Mayo Clinic Website. Iron Deciency Anemia. Date accessed August 2022. https://www.mayoclinic.org/diseases-conditions/iron-deciency-anemia/symptoms-causes/syc-20355034
  2. Cappellini MD, Musallam KM, Taher AT. Iron deciency anaemia revisited. J Intern Med. 2020;287(2):153-170. doi:10.1111/joim.13004
  3. National Institute of Diabetes and Digestive and Kidney Disease Website. Anemia in Chronic Kidney Disease. Date accessed August 2022. https://www.niddk.nih.gov/
  4. Fishbane S, Spinowitz B. Update on anemia in ESRD and earlier stages of CKD: Core curriculum 2018. American Journal of Kidney Diseases. 2018;71(3):423–435. doi:10.1053/j.ajkd.2017.09.026